Guanylyl cyclase c
|
guanylate cyclase 2C (heat stable enterotoxin receptor)
|
|
| Identifiers | |
| Symbol | GUCY2C |
| Alt. Symbols | GUC2C |
| Entrez | 2984 |
| HUGO | 4688 |
| OMIM | 601330 |
| RefSeq | NM_004963 |
| UniProt | P25092 |
| Other data | |
| EC number | 4.6.1.2 |
| Locus | Chr. 12 p12 |
Guanylyl cyclase c, or GC-C, is an enzyme found only in the lumen|luminal aspect of intestinal epithelium. The receptor has an extracellular ligand-binding domain, a single transmembrane region, a region with sequence similar to that of protein kinases, and a C-terminal guanylyl cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell.
Contents |
Functions
GC-C is a key receptor for heat-stable enterotoxins which are responsible for acute secretory diarrhea. Heat-stable enterotoxins are produced by pathogens such as Escherichia coli. Knockout mice defficient in the GC-C gene do not show secretory diarrhea on infection with E. coli, though they do with cholera toxin. This demonstrates the specificity of the GC-C receptor.
Diagnostic application
Because GC-C is tissue-specific for intestinal epithelium, it can be used for exceedingly precise detection of metastatic disease. The presence of GC-C mRNA can be detected at a rate of a single cancer cell out of 10,000,000 normal cells. This is the most precise staging tool available.
See also
External links
|
|||||
Why are we here?
All text is available under the terms of the GNU Free Documentation License
This page is cache of Wikipedia. History